The Peter Attia Drive #30 - Thomas Seyfried, Ph.D.: Controversial discussion—cancer as a mitochondrial metabolic disease?
02:48:06
Vagal Nerve Stimulation and Appetite
- Seyfried recounts a conversation about a vagal nerve stimulator used for epilepsy.
- This discussion highlighted the body's internal system to regulate caloric intake, particularly with high-fat diets.
Caloric Restriction Mimics Fasting
- Caloric restriction, even without a ketogenic diet, can produce ketones and anti-seizure effects.
- A 35-40% caloric restriction in mice is equivalent to a water-only fast in humans.
Warburg Effect Explained
- Otto Warburg observed cancer cells fermenting even with oxygen present, unlike normal cells.
- He concluded their respiratory system was defective, a concept now known as the Warburg effect.
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Introduction
00:00 • 3min
The Warburg Effect and the Legend of Oto Warburg
02:35 • 1min
Is Cancer a Metabolic Disease?
03:52 • 1min
Biopse Could Exasperate Cancer?
05:18 • 3min
How Did You Become Interested in Brain Tumors in the Mouse?
08:44 • 3min
Ketogenic Diets for Epilepsy
11:29 • 3min
Is Your Drug Really Stopping Brain Tumors?
14:35 • 2min
Epilepsia
16:46 • 2min
The Effects of Calory Restrictions on Seizures
19:09 • 2min
What Happens When Your Diaphragm Can't Work?
21:38 • 1min
You Can't Stop It. Once the Momento, It's Like These Hiccups
23:04 • 2min
Epilepsy
24:51 • 2min
Epilepsy
26:40 • 2min
Keto Dieting
28:33 • 3min
The Pasteur Effect in Cancer Cells
31:47 • 4min
The Cancer Cells Are Producing Lactic Acid
35:38 • 4min
How Do You Quantify the Amount of Lactate Produced in a Cell Culture?
39:24 • 3min
Is There a Mutation in Cancer?
42:05 • 3min
Is the Warburg Effect a Cause Effect?
45:04 • 2min
The Slowest Growing Hepotoma Doesn't Ferment, Right?
47:14 • 3min
The Warburg Effect - Cellular Building Blocks
49:56 • 3min
Sub Straight Level Phosphorilation Is a T P
52:41 • 2min
Do You Have Sub Straight Level Phosphorulation?
54:16 • 2min
Do You Think There Is a Better Explanation for Why These Hypotheses Aren't Being Investigated?
56:27 • 2min
Is the Cancer Cell Taking Up Oxygen?
58:30 • 2min
Is There a T P Production in the Mitochondria?
01:00:01 • 2min
Mitocondria
01:01:56 • 2min
Is There a Ketogenic Diet That Reduces Blood Sugar?
01:04:12 • 2min
The Insolent Suspension Test
01:06:31 • 2min
Type 2 Diabetes
01:08:12 • 3min
Oroglucos Tolerance Tests - Is That the Case?
01:11:37 • 2min
Is Insolent a Growth Signal?
01:13:47 • 2min
Is Glycose the Most Abundant Amino Acid in Our Body?
01:15:26 • 2min
The Cellular Immune System of Cancer Patients
01:17:42 • 2min
The Bottom Line Is, Where Are They Getting Their Energy From?
01:19:42 • 5min
Is There a Sarcoma in My Quadrucept?
01:24:29 • 3min
Or Cardiac Miocites
01:27:37 • 2min
Cancer and Oxidatov Phosphorilation
01:29:48 • 4min
Lactate Dosis in Tumors?
01:33:42 • 2min
The Cancers Don't Need Blood, Blood Vases
01:35:48 • 2min
Do They Still Use It for Cancer?
01:37:40 • 2min
Malignant Melanoma
01:39:38 • 1min
What Is Macrofage Fusion?
01:41:07 • 2min
What Is the Problem With Macropages?
01:42:45 • 2min
Is Your Sting Getting There, Is It Still Oozing?
01:44:41 • 3min
The Linkage Between Mutae and Breast Cancer
01:47:14 • 3min
Inflammatory Ancotaxis
01:49:52 • 2min
Is There a Risk of Breast Cancer From a Ness Byopse?
01:51:32 • 2min
Breast Tumor
01:53:32 • 3min
Metastatic G B M
01:56:10 • 2min
The Mitochondrial One, Ridi?
01:58:23 • 2min
Is the Death Rate From Cancer Increasing?
02:00:29 • 2min
Cancer Mortality - 50 %?
02:02:21 • 2min
How to Integrate Standard of Care and Metabolic Therapy in Turkey
02:03:57 • 2min
Cancer Patients Are Frightened Out Because They're Not Getting Treatment
02:05:46 • 2min
Cancer Cells Can't Burn Key Tones
02:07:41 • 2min
Is Hyperbaric Oxygen a Therapy for Tumor Cell Death?
02:10:00 • 3min
Is There a Drug That Works for Brass Cancer?
02:13:12 • 2min
Cancer
02:14:48 • 3min
Cancer Survivor Medicine
02:18:11 • 2min
Is the Metabolic Therapy a Cure for GBM?
02:19:47 • 2min
Do You Think That GBM Would Be the Best Histology to Study This In?
02:21:40 • 2min
What's the Difference Between a Patient and a Clinical Trial?
02:23:51 • 2min
Is There a Constraint in the Production of Lactate?
02:25:53 • 2min
I Don't Believe It, What Do You Believe?
02:28:05 • 3min
I'd Love to Know What the Experiments Are, Ta?
02:31:16 • 2min
Cancer, What's Going On?
02:33:44 • 2min
The Definition of Insanity
02:35:45 • 3min
Are There Alternatives to Epilepsy?
02:38:25 • 2min
Cancer Is a Genetic Disease, Not a Metabolic Disease
02:40:38 • 3min
Cancer Research - Is There an Easy Path to Funding Cancer Research?
02:44:03 • 2min
Is There a Risk in Open Cranial Surgery?
02:45:37 • 3min
In this episode, Thomas Seyfried, a cancer researcher and professor of biology at Boston College, discusses a controversial view of cancer as a mitochondrial metabolic disease. Many topics related to the causes, treatments, and prevention of cancer are covered in this in-depth conversation.
We discuss:
- How Tom got interested in cancer research [9:00];
- Calorie-restricted ketogenic diets, fasting, and epileptic seizures [18:30];
- Otto Warburg and the Warburg effect [30:45];
- Germline mutations, somatic mutations, and no mutations [42:00];
- Mitochondrial substrate level phosphorylation: Warburg's missing link [51:30];
- What is the structural defect in the mitochondria in cancer? [1:02:00];
- Peter's near-death experience with the insulin suppression test while in ketosis [1:06:30];
- Insulin potentiation therapy and glutamine inhibition [1:13:15];
- The macrophage fusion-hybrid theory of metastasis [1:39:30];
- How are cancer cells growth dysregulated without a mutation? [1:47:00];
- What is the dream clinical trial to test the hypothesis that we can reduce the death rates of cancer by 50%? [2:03:15];
- How can the hypothesis be tested rigorously that structural abnormalities in the mitochondria impair respiration and lead to compensatory fermentation? [2:26:30];
- Case studies of GBM survivors [2:32:45]; and
- More.
Learn more at www.PeterAttiaMD.com