CEO Meeker & CFO Smith's Strategy To Build Rhythm Into The Leading Orphan Obesity Company

Recorded on 03/01/26

TD Cowen senior biotech analyst Phil Nadeau speaks with Rhythm CEO David Meeker and CFO Hunter Smith at TD Cowen’s 46th Annual Health Care Conference to discuss Rhythm's strategic vision for establishing itself as the premier company in the orphan obesity space. Rhythm leverages the melanocortin pathway to address severe, early-onset obesity disorders, and its strategy is structured around three main pillars: genetic obesities, hypothalamic obesity (HO), and Prader-Willi syndrome. Building on the successful launch of Imcivree in Bardet-Biedl syndrome (BBS), Rhythm is now preparing for what may be its most significant launch to date: Imcivree for the treatment of hypothalamic obesity. Rhythm is optimistic that Imcivree will set a new standard of care for HO, significantly improve patient outcomes, and generate considerable value for shareholders. Beyond HO, Meeker and Smith outlined additional opportunities for Rhythm’s melanocortin-4 receptor (MC4R) agonists in other rare obesity disorders. These include ongoing investigations in various genetic obesity conditions as part of the Phase III EMANATE trial, as well as progress in Prader-Willi syndrome, where Imcivree demonstrated proof-of-concept efficacy in late 2025. To ensure the long-term success of the MC4R franchise, Rhythm is advancing a comprehensive life cycle management strategy, which includes the clinical development of next-generation MC4R agonists such as bivamelagon and RM-718.

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