Bloody Minded Episode 42 - In The Lab: Rare Groups, Subgroups, Elutes and Fruit Loops | Advanced Blood Banking
Apr 15, 2025
Delve into the fascinating world of rare blood groups and their impact on transfusion medicine. Explore the complexities of blood types and how racial variations influence practices in blood banking. Learn about advanced techniques like enzyme treatments that help in identifying antigens and resolving discrepancies. Discover the importance of specific blood group systems like Kell, Duffy, and Kidd, while also uncovering the challenges posed by monoclonal antibodies. It's a deep dive into the intricate, often overlooked, aspects of blood banking.
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Duffy Null's Dual Impact
- Duffy null phenotype protects against malaria by blocking Plasmodium vivax entry.
- It also causes lower neutrophil counts known as Duffy Null Associated Neutrophil Count (DANC).
Risks of Kidd Antibodies
- Anti-Kidd antibodies are dangerous and can cause severe hemolytic transfusion reactions.
- Anti-JKA is a common cause of delayed transfusion reactions and can be fatal.
Clinical Relevance of MNS Antibodies
- MNS blood group antibodies tend to be IgM and usually not clinically significant.
- Anti-M antibodies are common and often naturally occurring without transfusion history.