What is a self? Merely a human being? Or perhaps a soul? Hume claimed he could not find a self when he looked within, only a succession of impressions. But other philosophers seem to find transcendental selves, momentary selves, and objective selves, among others. Do the modern physical and biological sciences shed light on the self, or do they suggest there is no room – and no need – for such things? John and Ken examine their selves and others with Jenann Ismael from the University of Arizona, author of The Situated Self.