TWiV 1254: Clinical update with Dr. Daniel Griffin

Sep 20, 2025

Dr. Daniel Griffin, a seasoned clinician and infectious disease expert, joins to provide crucial insights on the evolving landscape of public health. He discusses the alarming increase in U.S. measles cases and highlights tragic complications like SSPE from this preventable disease. The conversation dives into the latest COVID-19 vaccine safety data, emphasizing its reliability for pregnant women. Dr. Griffin also explains new treatments for long COVID and stresses the importance of scientific integrity in health policy, urging listeners to advocate for robust biomedical research.

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INSIGHT

Single-Dose Baloxavir Reduces Flu Transmission

Baloxavir given as single dose to index flu patients reduced household transmission.
Resistance emerged in index patients but not seen in household contacts.

INSIGHT

Wastewater Tracks Community COVID Waves

Wastewater surveillance gives early, community-level signals of SARS-CoV circulation.
Current wastewater levels in parts of the U.S. are as high or higher than last winter's surge.

INSIGHT

Updated Moderna Vaccine Shows Strong Response

Moderna's 2025-2026 LP.8-targeted Spikevax produced an average >8-fold neutralizing antibody rise.
Preliminary safety matched prior studies per the company's press release.

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In his weekly clinical update, Dr. Griffin with Vincent Racaniello lament the anti-vaccine, anti-science composition of the ACIP, US cases of Chagas disease, the Ebola vaccination campaign in the DRC, the death of an infant in LA due to measles complications (SSPE), before Dr. Griffin deep dives into recent statistics on the measles epidemic, RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, use of monoclonal antibodies against influenza, the lack of adverse effects of the COVID-19 mRNA in both non-pregnant and pregnant women, where to find PEMGARDA, long COVID treatment center, where to go for answers to your long COVID questions, immune cell infiltration into the central nervous system during long COVID and contacting your federal government representative to stop the assault on science and biomedical research.

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Links for this episode

Northeast US states form health alliance in response to federal vaccine limits (Reuters)
MEETING OF THE ADVISORY COMMITTEE ON IMMUNIZATION PRACTICES (ACIP) (CDC: ACIP)
Viewpoint: Four tips for understanding this week’s ACIP meeting (CIDRAP)
From Data to Decisions: The Evidence Base for 2025 Fall/Winter Immunizations (CIDRAP)
Viewpoint: Four tips for understanding this week’s ACIP meeting (CIDRAP)
Vaccine Integrity Project (CIDRAP)
Chagas Disease, an Endemic Disease in the United States (CDC: Emerging Infectious Diseases)
Ebola vaccination begins in the Democratic Republic of the Congo (WHO: Democratic Republic of Congo)
Ebola Disease (WHO: African Region)
Wastewater for measles (WasterWater Scan)
Measles cases and outbreaks (CDC Rubeola)
L.A. child dies from complication of measles infection contracted in infancy (LA Times)
Tracking County-Level Measles Cases in the US (JAMA)
Tracking Measles Cases in the U.S. (Johns Hopkins)
Measles vaccine recommendations from NYP (jpg)
Weekly measles and rubella monitoring (Government of Canada)
Measles (WHO)
Get the FACTS about measles (NY State Department of Health)
Measles (CDC Measles (Rubeola))
Measles vaccine (CDC Measles (Rubeola))
Presumptive evidence of measles immunity (CDC)
Contraindications and precautions to measles vaccination (CDC)
Measles (CDC Measles (Rubeola))
Adverse events associated with childhood vaccines: evidence bearing on causality (NLM)
Measles Vaccination: Know the Facts (ISDA: Infectious Diseases Society of America)
Deaths following vaccination: what does the evidence show (Vaccine)
Influenza: Waste water scan for 11 pathogens (WastewaterSCan)
US respiratory virus activity (CDC Respiratory Illnesses)
Respiratory virus activity levels (CDC Respiratory Illnesses)
Weekly surveillance report: clift notes (CDC FluView)
Influenza Vaccine Composition for the 2025-2026 U.S. Influenza Season (FDA)
Efficacy of Baloxavir Treatment in Preventing Transmission of Influenza (NEJM)
RSV: Waste water scan for 11 pathogens (WastewaterSCan)
US respiratory virus activity (CDC Respiratory Illnesses)
RSV-Network (CDC Respiratory Syncytial virus Infection)
Vaccines for Adults (CDC: Respiratory Syncytial Virus Infection (RSV))
Economic Analysis of Protein Subunit and mRNA RSV Vaccination in Adults aged 50-59 Years (CDC: ACIP)
Evidence to Recommendations Framework (EtR): RSV Vaccination in Adults Aged 50–59 years (CDC: National Center for Immunization and Respiratory Diseases)
Waste water scan for 11 pathogens (WastewaterSCan)
COVID-19 deaths (CDC)
Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses)
COVID-19 national and regional trends (CDC)
COVID-19 variant tracker (CDC)
SARS-CoV-2 genomes galore (Nextstrain)
Antigenic and Virological Characteristics of SARS-CoV-2 Variant BA.3.2, XFG, and NB.1.8.1 (bioRxiV)
Moderna Announces Updated COVID-19 Vaccine Against LP.8.1 Variant Generates Strong Immune Response in Humans (Access Newswire)
Adverse events associated with COVID-19 vaccination or diagnosis among pregnant and non-pregnant women in the United States, 2021-2022 (International Journal of Infectious Diseases)
Where to get pemgarda (Pemgarda)
EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD)
Infusion center (Prime Fusions)
CDC Quarantine guidelines (CDC)
NIH COVID-19 treatment guidelines (NIH)
Drug interaction checker (University of Liverpool)
Infectious Disease Society guidelines for treatment and management (ID Society)
PAXLOVID-nirmatrelvir and ritonavir : highlights of prescribing information (Pfizer)
Help your eligible patients access PAXLOVID with the PAXCESS Patient Support Program (Pfizer)
PAXCESSTM offers access and affordability options to patients prescribed PAXLOVIDTM (nirmatrelvir tablets; ritonavir tablets) (PAXCESS)
Molnupiravir safety and efficacy (JMV)
Convalescent plasma recommendation for immunocompromised (ID Society)
What to do when sick with a respiratory virus (CDC)
Managing healthcare staffing shortages (CDC)
Anticoagulation guidelines (hematology.org)
Daniel Griffin’s evidence based medical practices for long COVID (OFID)
Long COVID hotline (Columbia : Columbia University Irving Medical Center)
The answers: Long COVID
CSF immune cell alterations in women with neuropsychiatric Long COVID (JID)
Reaching out to US house representative
Letters read on TWiV 1254
Dr. Griffin’s COVID treatment summary (pdf)
Timestamps by Jolene Ramsey. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Content in this podcast should not be construed as medical advice.