Ben Bikman, PhD | Reversing Insulin Resistance | The Metabolic Link Ep.9

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Mar 21, 2023

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ADVICE

Be Cautious With Insulin Therapy

Avoid default insulin therapy as first-line in type 2 diabetes when possible because extra insulin worsens weight, metabolic rate, and mortality risk.
Consider strategies that lower insulin rather than chronically increasing it.

ANECDOTE

Rapid Triglyceride Drop Case

David Unwin reported a patient whose triglycerides fell from ~800 to ~60 in eight weeks after carbohydrate reduction.
This dramatic drop illustrates how lowering insulin rapidly reduces hepatic triglyceride production.

INSIGHT

Insulin Receptors Are Ubiquitous

Virtually every cell expresses an insulin receptor, so insulin has bodywide effects beyond glucose metabolism.
Insulin signaling influences tissues even without mitochondria or GLUT4 expression.

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On this week’s episode of The Metabolic Link, Dr. Dominic D’Agostino is sitting down with world-renowned metabolic scientist, Ben Bikman, PhD, to explore the ins and outs of insulin resistance, Type 2 Diabetes Mellitus (T2DM), and ways to manage, and even reverse, both.

In this discussion, Dr. Bikman makes a case for why testing fasting insulin should be a part of the diagnostic and treatment equation when addressing T2DM, the difference between pathological and physiological insulin resistance, and how insulin therapy affects metabolic physiology in T2DM. Dr. Bikman explains that while insulin is necessary for healthy living, it can elicit significant and harmful changes in tissue metabolic function when chronically elevated. Dr. D’Agostino and Dr. Bikman also dive into the relationship between triglycerides and insulin, and some of his latest research in the lab.

Dr. Ben Bikman has a Ph.D. in Bioenergetics and completed a postdoctoral fellowship with the Duke-National University of Singapore in metabolic disorders. His research focus is to elucidate the molecular mechanisms that mediate the disruption that causes and accompanies metabolic disorders, such as obesity, type 2 diabetes, and dementia. Driven by his academic training, he is currently exploring the contrasting roles of insulin and ketones as key drivers of metabolic function. He is a highly accomplished scientist with numerous publications in high impact journals and international presentations.

In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!

In every episode of The Metabolic Link, we'll uncover the very latest research on metabolic health and therapy. If you like this episode, please share it, subscribe, follow, and leave us a comment or review on whichever platform you use to tune in!

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Please keep in mind: The Metabolic Link does not provide medical or health advice, but rather general information that does not serve as a substitute for a licensed healthcare professional. Never delay in seeking medical advice from an appropriately licensed medical provider for any health condition that you may have.