Blood Bank Guy Essentials Podcast 088: Warm Autoantibody Best Practices with Alyssa Ziman and Meghan Delaney
Jan 27, 2021
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Warm Autoantibody Basics
- Warm autoantibodies are IgG that react best at 37°C and often appear as panagglutinins in eluates or serum panels.
- They can exist without autoimmune hemolytic anemia, so presence of a warm auto does not equal active hemolysis.
Use Saline/IgG First In Urgent Workups
- Use less-sensitive methods like saline IgG or dilution studies first to screen for underlying alloantibodies in urgent settings.
- If saline IgG removes reactivity, avoid time-consuming adsorption studies and proceed to select units.
When To Use Auto vs Allo Adsorptions
- Choose auto-adsorption if the patient has no transfusion/pregnancy within 3 months and you have enough patient cells.
- Use allo-adsorption when recent transfusion/pregnancy prevents a reliable auto-adsorption.