The Optispan Podcast with Matt Kaeberlein Dr. Matt Ranks Longevity Supplements: The Winners and Total Scams
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Feb 15, 2026 An evidence-based tour of 13 popular longevity supplements with clear rankings. Conversation digs into which compounds show reproducible biology and which rely on hype. Safety, dosing, contamination and measurement tips come up repeatedly. Practical picks and risky or overhyped products are highlighted for listeners deciding what to try.
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Use Creatine With Resistance Training
- Take 3–5 g/day creatine and do regular resistance training for measurable benefits.
- Creatine improves body composition and may protect brain energy under stress.
CoQ10’s Benefits Are Contextual
- CoQ10 helps in specific mitochondrial or cardiac conditions but lacks general longevity evidence.
- Routine supplementation is unlikely to meaningfully affect aging in healthy people.
Avoid SS Peptides For Now
- Avoid SS peptides like SS-31 unless you have a mitochondrial disorder and a trusted prescription.
- Purity, dosing, long-term safety, and benefits in healthy people remain uncertain.