The Optispan Podcast with Matt Kaeberlein

Brain Aging & Alzheimer’s Prevention: The Future of Cognitive Health Testing | Dr. Christin Glorioso | 106

Mar 18, 2025
Dr. Christin Glorioso, founder of NeuroAge Therapeutics, dives into the cutting-edge landscape of brain aging and Alzheimer’s prevention. Discover how innovative tests predict Alzheimer’s risk decades ahead, combining genetic insights with lifestyle choices. Glorioso discusses the power of diet, exercise, and sleep on cognitive health, alongside the latest advancements in medications like GLP-1 agonists. Plus, learn about the fascinating role of MRI scans and neural games in assessing brain health, making a compelling case for the future of cognitive well-being.
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ADVICE

Target Six Brain-Healthy Habits

  • Focus on six lifestyle domains: exercise, sleep (7–8 hours), Mediterranean diet, social connection, mental activity, and stress reduction.
  • Glorioso highlights stress management because cortisol harms neurons.
INSIGHT

Amyloid Drugs: Partial Win With Risks

  • Anti-amyloid antibody therapies remove plaques and show modest cognitive benefit (~20–30%) but carry risks like ARIA in ~20% of patients.
  • Glorioso frames amyloid as one modifiable risk factor among many, not a sole cause.
INSIGHT

GLP-1 Drugs May Protect The Brain

  • Observational data link GLP-1 agonist use in diabetes to lower dementia incidence versus other diabetes drugs.
  • Proposed mechanisms include PI3K pathway activation and direct neuroprotection beyond weight loss.
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