Mast Cell Matters: Deep dives on MCAS with Tania Dempsey, MD - Presented by The POTScast

Dr. Alexis Cutchins on venous compressions, POTS, MCAS, MALS and more

Jun 10, 2025
In this engaging discussion, Dr. Alexis Cutchins, an assistant professor at Emory specializing in cardiovascular disease in women, dives into the intricate connections between MCAS, POTS, and venous compression. She shares insights on how these conditions impact patients, highlighting the importance of pelvic venous health. The conversation also covers the significance of ongoing medical education and the evolving dynamics between patients and doctors in addressing these complex disorders.
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ADVICE

Managing MCAS Reactivity Post-Stenting

  • Patients with MCAS may face temporary symptom flares after venous stenting, treatable with steroids and mast cell therapies.
  • Long-term reactions to stents are rare after endothelialization occurs within 6-12 months.
ANECDOTE

Patient Reports MCAS Improvement Post-Stent

  • Some patients report feeling less reactive to triggers within a month after pelvic venous stenting.
  • This anecdotal evidence suggests a calming effect on systemic mast cell activation after pelvic congestion relief.
ADVICE

Alternatives to Venous Stenting

  • Consider ultrasound shockwave therapy or fascial counter strain as non-invasive options for pelvic venous congestion.
  • Anticoagulation helps but does not fix venous compression, which often requires mechanical relief like stenting.
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