Two Onc Docs Hodgkin Lymphoma 2025 UPDATE
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Nov 24, 2025 The podcast dives into the latest updates on Hodgkin Lymphoma, covering critical aspects like its pathology and staging. It highlights the differences between classical and nodular lymphocyte-predominant types and discusses the significance of Deauville PET scoring in treatment evaluation. There’s a thorough exploration of chemotherapy regimens, including the potential of immunotherapy for advanced stages. Additionally, the episode addresses long-term survivorship issues, from late effects to fertility and cardiopulmonary concerns.
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IPS Score Predicts Survival
- The IPS prognostic score uses SAW MEAL mnemonic to predict 5-year OS differences from ~80% to ~60%.
- Higher IPS correlates with worse survival but outcomes are improving with new therapies.
Memorize The Four-Stage Rule Of Thumb
- Stage by nodal distribution: I single region, II same side of diaphragm, III both sides, IV disseminated.
- Always note modifiers: A/B (B symptoms), E (extranodal), S (spleen).
Use Deauville 1–3 As Remission Cutoff
- Use Deauville scoring on PET after two cycles to guide therapy: 1–3 = remission, 4–5 = active disease.
- Compare uptake to mediastinum and liver when assigning scores.