Smart Biotech Scientist | The CMC and Bioprocessing Podcast for Process Development and Manufacturing Leaders 195: Monolithic Chromatography Innovations: Solving High-Capacity Purification for Gene Therapy Vectors with Alois Jungbauer - Part 1
In this episode, host David Brühlmann is joined by Alois Jungbauer, Professor Emeritus at BOKU University, Vienna, and Scientific Advisor at BioChromatographix International. With over 40 years in bioprocess engineering and more than 400 published papers, Jungbauer offers a unique perspective on how downstream processing and purification technologies have evolved and where they’re headed next.
Alois shares his unconventional journey into the world of biotech, starting from humble beginnings on an Austrian farm, and discusses key turning points that have shaped the industry. Together, they explore the latest challenges triggered by high cell culture titers, new therapeutic modalities, and the drive for automation and process integration in manufacturing.
In this episode:
- Why the gap between upstream and downstream processes remains a core bottleneck (03:27)
- How rigid and convective chromatography materials changed throughput and efficiency (06:56)
- The shift in purification strategies with skyrocketing titers in cell culture (08:43)
- Automation and integrated biomanufacturing: their role in making processes more robust and continuous (10:20)
- Misconceptions around resin costs in full-scale versus clinical-scale manufacturing (12:10)
- What automation and process monitoring mean for real-time release and factory scheduling (14:05)
- The resurgence and application of displacement chromatography for gene therapy vectors (15:49)
Whether you’re deep into process development or just curious about the next wave in biotech manufacturing, Alois Jungbauer’s insights offer valuable context for the road ahead.
Connect with Alois Jungbauer:
LinkedIn: www.linkedin.com/in/alois-jungbauer-14984811
Website : www.biochromatographix.com
Next step:
Book a 20-minute call to help you get started on any questions you may have about bioprocessing analytics: https://bruehlmann-consulting.com/call
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