How AI Cut Drug Discovery From 8 Years to 4 Years | Alice Zhang's Moneyball Approach

What happens when you realize in middle school that the greatest impact you can make is solving humanity's most complex diseases? On this episode of the 1st10 Podcast, host Boris Epstein sits down with Alice Zhang, founder and CEO of Verge Genomics, to unpack why drug discovery has been stuck for decades - and why AI, used the right way, might finally change that. Alice dropped out of a prestigious UCLA MD-PhD program to build an AI-powered drug discovery company that's rewriting the rules of biotech. In this conversation, Alice reveals:Why relying on mouse models to predict human drug responses has led to a 90% failure rate in clinical trialsHow conducting 1,200+ interviews helped Alice build a rare team of engineers and scientists fluent in both machine learning and biologyThe conscious culture framework that eliminates workplace dramaHow Verge compressed the traditional 8-year, hundreds-of-millions-dollar journey from discovery to clinical trials down to just 4 yearsWhy it is a problem that we fundamentally don't understand what causes the diseaseSpecifically, don't miss the part where Alice predicts why the pharmacological research industry will move away from the current hybrid model and what it is likely to split into!Chapters:00:00 - Episode Preview02:05 - Introductions05:05 - Small Questions, Big Implicationsg13:18 - "Just Start" ALWAYS Beats Confidence16:21 - The Mouse Problem22:40 - Beating ChatGPT To The ChatGPT Moment28:26 - 3 Areas for AI-IMpact In Drug-Development33:22 - Why Are Drugs Are So D*** Expensive?!35:07 - Building A Dataset That No One Else Has39:31 - "Conscious Culture" Careers at Verge49:35 - A 2026 Prediction Most Founders Won't Like52:09 - Contact Details and Life LessonsQuotes:"The feeling I wanted to have was that I had made a big impact and left a legacy on the world." - Alice Zhang (05:27)"A mouse swimming in a water bath is not going to predict whether a human loses their memory faster or slower." - Alice Zhang (16:14)"No transformative technology from day one has ever been a smashing success." - Alice Zhang (23:49)"The problem with Alzheimer's disease is not that we don't have a drug against it. It's that we completely have no idea what causes Alzheimer's disease." - Alice Zhang (33:52)"Sometimes the best trick for catching a wave isn't actually working hard, it's being at the right position at the right time." - Alice Zhang (52:09)Follow:Spotify: https://podcasters.spotify.com/pod/show/1st10podcast Amazon: https://music.amazon.com/podcasts/7e8ec9af-f38c-4cd9-8c68-1c1dd4516b 27/1st10-podcastApple: https://podcasts.apple.com/us/podcast/1st10-podcast/id1760411207 Podcast: https://www.1st10.com/podcast RSS: https://anchor.fm/s/f951319c/podcast/rss YouTube: https://www.youtube.com/@1st10podcast Links:Alice Zhang on LInkedIn: https://www.linkedin.com/in/alice-zhang-2087862b/Verge Genomics: https://www.vergegenomics.com/Alice Zhang on ResearchGate: https://www.researchgate.net/profile/Alice-Zhang-8Music by Roman Senyk from PixabayProducer: Shrikant Joshi