The Stem Cell Podcast

Ep. 84: “Visual Restoration” Featuring Dr. Deepak Lamba

Jan 31, 2017
Dr. Deepak Lamba, an assistant professor at the Buck Institute who pioneers making retinal cells from stem cells. He discusses lab methods to generate retinal cell types. He talks about translating dish-grown cells toward clinical safety and integration. He covers immune challenges in degenerating eyes and strategies to limit rejection and modulate inflammation.
Ask episode
AI Snips
Chapters
Transcript
Episode notes
INSIGHT

Eye Cells Grown By Replaying Embryonic Signals

  • Deepak Lamba directs stem cells to retinal fates by recapitulating embryonic eye development cues in vitro.
  • His lab guided pluripotent cells to head-side identity then eye identity, enabling light-sensing photoreceptor production used for transplantation tests.
ANECDOTE

How A PhD Project Became A Vision Therapy Program

  • Deepak Lamba started this work during his PhD by combining human pluripotent cells with embryology knowledge from eye-development labs.
  • He recalls being surprised that guided culture conditions reliably produced eye tissue, which launched his long-term translational efforts.
INSIGHT

Degenerating Eyes Lose Immune Privilege

  • The eye's immune privilege can fail during degeneration, allowing immune cells and inflammation to block transplanted cell survival.
  • Lamba tested this against field dogma and used targeted funding to probe immune pathways that destroy grafts months after transplant.
Get the Snipd Podcast app to discover more snips from this episode
Get the app