Based Camp | Simone & Malcolm Collins

Neural Tissue Comp Now Cheaper Than Silicon! (This Changes Everything)

Mar 11, 2026
They unpack neuron-powered wetware that can run games and outcompete silicon on cost and power. They explore ethical alarms around lab-grown brains, pain pathways, and identity. They speculate about hybrid silicon-neural-quantum systems, spacefaring brain ships, and who gets left behind. Cultural and theological angles surface alongside wild thoughts on uploads, speciation, and new forms of intelligence.
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ADVICE

Try Wetware As A Service Before Buying Hardware

  • Experimenters can access wetware incrementally via remote developer subscriptions without running a lab.
  • Cortical Labs offers wetware-as-a-service so startups can test hybrid agents by renting human-neuron compute remotely.
ANECDOTE

Malcolm's Default Agent Is A Simone Clone

  • Malcolm uses a playful personal example: his RFAB agent default template is Simone and he frequently seeds agents with her persona.
  • He says he would clone Simone as a trustworthy default agent because she maintains robust alignment.
INSIGHT

Long-Lived Organoids Develop Humanlike Wiring

  • Long-lived organoids develop human-like neural wiring over years, enabling developmental research and disease modeling.
  • Teams have kept pea-sized organoids with ~2 million neurons alive for seven years and seen kindergarten-like wiring emerge.
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