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One Night Off CPAP Shifts Alzheimer Biomarkers
- One night off CPAP produced measurable increases in plasma neurofilament light and decreases in plasma Aβ42 compared with a treated night.
- Mount Sinai measured before-and-after sleep blood draws on adherent severe OSA patients after two nights off CPAP versus a therapeutic CPAP night using Simoa assays.
Neurofilament Light Signals Acute Neural Injury
- Neurofilament light (NfL) rises with neural injury and tracks Alzheimer progression, rising from normal to MCI to dementia.
- NfL increases in plasma predict worse cognition even in cognitively normal people, making it a sensitive acute injury marker.
Simoa Enables Plasma Alzheimer Biomarker Studies
- Plasma Alzheimer biomarkers are now measurable using ultrasensitive Simoa technology, enabling overnight blood studies instead of CSF or PET.
- This allowed Mount Sinai to detect tiny changes in Aβ42 and NfL without lumbar puncture or PET imaging.