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Paracetamol Works Mainly In The Brain
- Paracetamol acts mainly centrally in the brain reducing temperature and influencing the pain centre rather than strongly reducing peripheral inflammation.
- Mary Joan McLeod explains this is why paracetamol works less well for inflamed injuries like a twisted ankle compared with NSAIDs.
Do Not Mix Two Paracetamol Products
- You can combine paracetamol with ibuprofen or aspirin but avoid taking two paracetamol products simultaneously to prevent overdose.
- Mary Joan McLeod warns mixing is acceptable yet warns careful dose checking across products is essential.
Buy Capsules If You Need Quicker Relief
- Capsules and liquid formulations dissolve and absorb faster than solid tablets, so they may relieve pain sooner despite identical drug doses.
- Mary Joan McLeod explained caplets use different excipients to dissolve quicker than standard tablets.


