The Oprah Podcast

Serena Williams and Oprah on Deciding to Take GLP-1 Medications

4 snips
Jan 13, 2026
Dr. Ania Jastreboff, an endocrinologist at Yale and author of 'Enough,' joins former tennis champion Serena Williams to explore the transformative potential of GLP-1 medications. They discuss the misconception of obesity as a lack of willpower, instead framing it as a complex disease influenced by biology. Serena shares her journey with postpartum weight and how GLP-1s helped her conquer her toughest opponent. The conversation also highlights real-life testimonials from audience members who experienced life-changing results.
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ANECDOTE

Immediate Relief From Food Noise

  • Oprah says the food noise subsided the day after her first GLP‑1 dose.
  • She described immediate relief from constant thoughts about food.
INSIGHT

How GLP‑1s Recalibrate Hunger

  • GLP-1 medications act on the brain to lower the body's enough point.
  • They reduce persistent hunger and recalibrate how much the body wants to carry.
ANECDOTE

Serena’s Struggle And Breakthrough

  • Serena Williams struggled to lose weight despite elite training and long workouts.
  • She lost 31 pounds on a GLP‑1 and felt joint relief, more energy, and greater freedom.
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