Locked On 49ers - Daily Podcast On The San Francisco 49ers

49ers Keys to Victory vs the Carolina Panthers on Monday Night Football

Nov 21, 2025
The discussion centers on the 49ers' game plan against the Panthers, including a deep dive into rookie Tetairoa McMillan's rising threat. There’s a debate on how best to defend against him, especially in the red zone. Ricky Pearsall's role is also highlighted as he returns to the lineup. The hosts emphasize the importance of a strong run game with McCaffrey to bolster the defense. Plus, questions arise about the 49ers' kicking situation and their ability to handle close matchups.
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ADVICE

Limit McMillan With Bracketing

  • Bracket or 'put a cap on' McMillan to limit his big-play upside, using extra defenders or over-the-top help.
  • Match personnel (e.g., bigger corners or safeties) to avoid one-on-one mismatches in the red zone.
INSIGHT

Matchup Discrepancy Looms Large

  • Upton Stout's size mismatch versus McMillan (5'8.5" vs 6'5") is an exploitable target for Carolina.
  • Opponents will likely scheme to force that mismatch or use slot moves to put smaller corners on McMillan.
ADVICE

Force The 49ers To Adjust

  • Test the 49ers' tendency not to move corners by putting McMillan in the slot and forcing them to adjust their coverage.
  • If they don't follow, exploit the slot matchup against smaller or static defenders.
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