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OSA Is Fundamentally Heterogeneous
- Obstructive sleep apnea is a heterogeneous disorder across symptoms, physiology, and outcomes.
- Phenotyping seeks data-driven subgroups to tailor diagnosis and treatment.
Iceland Cohort Revealed Three Symptom Subtypes
- In the Icelandic cohort cluster analysis produced three symptom subtypes: disturbed sleep, minimally symptomatic, and excessively sleepy.
- These subtypes had similar AHIs, showing symptoms didn't track severity.
Symptom Subtypes Replicate Internationally
- The three symptom subtypes replicated across multiple international cohorts with variable optimal cluster counts.
- A clinician tool is being developed to assign patients to these subtypes.