The Metabolic Link

The Metabolic Management of Migraines | Elena Gross, PhD | The Metabolic Link Ep. 15

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May 23, 2023
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ANECDOTE

Desperation That Sparked Her Career

  • Elena recalled suicidal thoughts during a month-long continuous migraine and the despair of losing control.
  • That crisis motivated her to study neuroscience and seek metabolic solutions.
INSIGHT

Brain Energy Has Little Redundancy

  • The brain has tiny energy storage and depends on blood-delivered fuels across the blood-brain barrier.
  • Glucose, lactate, and ketone bodies are its primary fuels with limited redundancy.
INSIGHT

Hyperexcitable Brains Use More Energy

  • Many migraine brains are hyperexcitable and spend ~20% more energy than healthy brains between attacks.
  • Combined with impaired energy metabolism this creates a high migraine susceptibility.
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