The Optispan Podcast with Matt Kaeberlein

Testosterone, Rapamycin & Diet Myths: A Scientist's AMA | 124

Aug 19, 2025
Dr. Matt Kaeberlein answers burning questions about testosterone therapy and the longevity drug rapamycin. He explains his own injection protocol and offers insights on its use for women. The discussion highlights the pitfalls of excessive supplement regimens and debunks common diet myths, including time-restricted eating. Matt also clarifies the differences between DEXA scans and their importance for body composition. Stick around for entertaining tales from his Ireland trip featuring Guinness and whiskey!
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ADVICE

Testosterone Consideration For Women

  • Measure hormones regularly if considering testosterone for women under chronic stress or calorie restriction.
  • Use testosterone as part of supervised hormone therapy to protect muscle, mood, libido, and metabolic health when indicated.
INSIGHT

When Rapamycin May Make Sense

  • Evidence for rapamycin in people in their 30s is limited, so benefits for longevity are speculative.
  • Consider rapamycin earlier mainly for specific conditions like autoimmune disease, long COVID, or APOE4 risk.
ADVICE

Pause Rapamycin For Bacterial Illness

  • Stop rapamycin during bacterial infections and consider pausing for significant infections.
  • If metabolic or blood changes occur, reduce dose or check levels and reassess risk–benefit with your provider.
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