24 – From Wharton to Amazon: Business Model Innovation in Action

Your host Alex Shevelenko welcomes Sergey Netessine, Senior Vice Dean of Innovation and Global Initiatives at the Wharton School and Durbani Armani Professor of Innovation and Entrepreneurship. Sergey is also an Amazon Scholar and a seasoned investor, bringing a rare blend of academic rigor, corporate strategy, and hands-on venture experience to the world’s leading organizations.

In this conversation, Sergey shares his perspective on business model innovation, corporate-startup collaboration, and the role of culture in driving organizational change. He explains why the biggest barrier to innovation in large companies is not technical, but cultural, and contrasts this with the experimentation-driven mindset of startups. Sergey also discusses his unique approach to investing—not for returns, but for learning and insight—and how he integrates these experiences into teaching and research at Wharton.

From his work shaping Wharton’s executive education programs and global youth initiatives to advising major companies like Amazon, Sergey illustrates how to bridge theory and practice, build disciplined investment processes, and nurture lifelong learning. This episode shows how curiosity, experimentation, and a structured approach can unlock innovation, both personally and organizationally.

To continue the conversation with Sergey, connect with him via his LinkedIn or the Wharton website.

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