JACC This Week

October 14, 2025 - Emerging Frontiers in Cardiovascular Medicine: From Certification Reform to Inflammation Targeting | JACC This Week

Oct 6, 2025
Delve into the modernization of physician certification with a focus on core knowledge and clinical reasoning. Explore the link between clonal hematopoiesis and cardiovascular risks in older women. Discover how third-generation LVADs improve clot outcomes, despite bleeding risks, and learn about dapagliflozin's impact on heart failure events post-TAVI. Find out how inflammation targeting post-myocardial infarction can aid healing and discuss the expanding role of drug-coated balloons in PCI. Plus, the growing use of cardiac CT for assessing prosthetic valves.
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ADVICE

Modernize Physician Certification

  • Reframe certification into core facts and decision-making skills with distinct assessment methods.
  • Use frequent microlearning for type 1 facts and open-book simulations for type 2 reasoning to encourage lifelong learning.
INSIGHT

CHIP Is Heterogeneous And Cardiovascularly Relevant

  • Clonal hematopoiesis (CHIP) rises with age and drives inflammation that links to cardiovascular disease.
  • Different mutations (TET2, ASXL1, JAK2) associate with distinct cardiac outcomes, making CHIP heterogeneous.
ADVICE

Rethink Anticoagulation After LVAD Stabilization

  • Reassess anticoagulation strategies after the early LVAD stabilization period and test alternatives like DOACs.
  • Design trials to fine-tune bleeding versus thrombosis balance, especially with third-generation pumps.
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