Count to 10 - Anaesthetic Primary Podcast EP31 – Propofol TCI Pharmacokinetics with Dr Anthony | CT10
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Jan 12, 2025 Dr. Anthony Haidt, an esteemed primary exam examiner and anesthesia specialist, joins to explore the complexities of propofol pharmacokinetics and Target Controlled Infusion (TCI). He breaks down vital equations and utilizes analogies, like a bucket analogy, to clarify rate constants and drug compartment models. The conversation covers age and weight variations in anesthesia dosing, practical applications for clinicians, and the significance of understanding the Marsh and Eleveld models in patient safety. It’s a must-listen for anyone looking to deepen their anesthesia knowledge!
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Real-time Examples
- Use SimTIVA or a real TIVA pump to test examples in real-time.
- This solidifies knowledge and understanding of propofol TCI concepts.
Understanding V1
- V1, the initial volume of distribution, represents the relationship between the bolus dose and the initial peak plasma concentration.
- Different V1 values in textbooks reflect varying models, not actual physical volumes.
Age and Volume Distribution
- Children have higher volume distribution, requiring larger boluses of propofol.
- Elderly people have lower volume distribution, needing smaller doses.
