Long Covid Podcast 187 - Energy Crisis: How Your Cell's Power Plants are Hijacked
Sep 17, 2025
Dr. Robert Groysman, a dual-boarded anaesthesiologist and pain specialist, dives into the complexities of Long Covid. He reveals six key mechanisms including mitochondrial dysfunction, which is crucial for energy production but can be damaged by COVID-19. Dr. Groysman emphasizes the importance of pacing to avoid post-exertional malaise and outlines a two-step recovery protocol that combines antioxidant support with careful mitophagy. His insights shed light on the multi-faceted nature of Long Covid and the need for a tailored treatment approach.
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Long COVID Is Multi‑Mechanism
- Long COVID commonly involves multiple biological mechanisms at once rather than a single cause.
- Robert Groysman lists six major mechanisms that often coexist and interact in patients.
Mitochondria Vary By Cell Energy Need
- Mitochondria generate most cellular ATP and their density varies by cell type based on energy needs.
- High-energy cells like neurons, myocytes and heart cells contain many more mitochondria than others.
Mitochondria Produce Oxidative Waste
- Mitochondria operate at roughly 40% efficiency and produce reactive oxygen species as waste.
- Those oxidative byproducts can damage mitochondria and raise cellular oxidative stress.
