Ep. 41 Advanced Pancreatic Cancer: Systemic Therapy Strategies with Dr. Shubham Pant

Metastatic pancreatic cancer is no longer a ‘one size fits all’ diagnosis. In this episode of the BackTable Tumor Board Podcast, medical oncologist Dr. Jon Mizrahi and Dr. Shubham Pant, a professor of GI Medical Oncology at MD Anderson Cancer Center, discuss the evolving landscape of systemic therapy for advanced pancreatic cancer.
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SYNPOSIS
The doctors cover the current options for first- and second-line chemotherapy treatments, the significance of molecular profiling and germline testing, and the emerging potential of targeting KRAS mutations. The discussion also highlights the importance of supportive and palliative care for patients, focusing on pain management, nutritional support, and the role of pancreatic enzymes. The conversation concludes with speculation on the future of pancreatic cancer treatment and the need for improved access to clinical trials.
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TIMESTAMPS
00:00 - Introduction
02:32 - First-Line Therapy Options
10:31 - Second-Line Therapy Options
20:18 - Challenges in Pancreatic Cancer Immunotherapy
26:47 - Supportive Care and Quality of Life
35:57 - Disparities in Pancreatic Cancer Treatment
38:58 - Conclusion and Future Directions
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RESOURCES
Adagrasib Clinical Trial
https://www.clinicaltrials.gov/study/NCT05853575