Bloody Minded Episode 50 - Washed Out | Approach to Anaemia
Jun 24, 2025
Uncover the mysteries of anemia in a lively discussion! Explore the importance of blood cell counts, and learn about various types of anemia, including microcytic and macrocytic cases. Delve into thalassemia, iron deficiency, and even lead poisoning with a humorous twist. The hosts simplify complex concepts, making them accessible for medical novices. Plus, discover surprising links between anemia and lifestyle factors like diet and drug use. This enjoyable blend of education and entertainment is sure to make hematology engaging!
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Chronic Disease Anemia Mechanism
- Anemia of chronic disease is a functional iron deficiency caused by inflammation hiding iron stores.
- It can present as normocytic or microcytic anemia with normal/increased ferritin and low or normal transferrin.
Sideroblastic Anemia and Iron Overload
- Sideroblastic anemia arises from defective heme synthesis causing iron build-up in mitochondria forming ring sideroblasts.
- It is rare, can be congenital or acquired, and often shows microcytic anemia with signs of iron overload.
Hemolysis Screen Essentials
- To work up hemolytic anemia, order conjugated bilirubin, haptoglobin, LDH, reticulocyte count, DAT, and always review the blood film.
- Normal or raised haptoglobin excludes hemolysis; combined test results help confirm diagnosis.