The Dr. Tyna Show

Weight Gain on HRT: What’s Really Causing It | Solo

Feb 7, 2026
An honest dive into why hormone replacement can sometimes lead to weight gain. Short explanations on how estrogen, progesterone and testosterone affect appetite, insulin and body composition. A discussion of the Goldilocks hormone range, progesterone-driven carb cravings, and transient insulin resistance. Practical focus on muscle, microdosing, and metabolic strategies to reduce unwanted weight changes.
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INSIGHT

Goldilocks Hormone Window

  • Hormones require a Goldilocks range: too high or too low can trigger problems like insulin resistance.
  • Perimenopause shifts this sweet spot month-to-month, complicating HRT dosing.
ADVICE

Build Muscle Before Starting HRT

  • Do prioritize strength training and build muscle before or when starting HRT to create a glucose sink.
  • Do not rely on hormones alone; pair HRT with consistent exercise to mitigate metabolic risk.
INSIGHT

HRT And Insulin Resistance Trade-Off

  • HRT can induce insulin resistance but so can low hormones; both extremes hurt metabolic health.
  • Strength training and muscle are critical to offset hormone-driven insulin effects.
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