Neurotech Daily 9. Personalizing neuromodulation by Neurotwin with Neuroelectrics | Edmundo Lopez-Sola
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Oct 30, 2023 Edmundo Lopez-Sola, Senior Brain Modeling Researcher at Neuroelectrics who builds personalized computational brain models. He talks about NeuroTwin digital brain replicas and how they simulate and optimize noninvasive stimulation. He covers data needs like MRI and EEG, model-driven clinical trials for epilepsy, depression and Alzheimer’s, and the vision for supervised at-home stimulation.
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Digital Brain Twins Guide Personalized Stimulation
- NeuroTwin are digital twins of patient brains used to predict responses to transcranial electrical stimulation and optimize electrode placement and currents.
- Models include disease-relevant features like patient tractography from diffusion MRI and EEG seizure propagation patterns for epilepsy.
Choose Only Disease Relevant Data For Models
- Select input data by the biomarkers you need to reproduce for the target pathology rather than collecting everything by default.
- For example, use MRI and DTI for current distribution and connectomes, and EEG or intracranial EEG for epilepsy biomarkers.
Alzheimer's Home Stimulation Trial Used NeuroTwin Models
- Neuroelectrics applied NeuroTwin-driven tACS in an Alzheimer’s trial delivering home stimulation supervised by a hospital partner.
- They built neurotwins from patient data to optimize protocols aimed at increasing gamma activity before home deployment.