The mindbodygreen Podcast 649: Why “in range” lab results aren’t the solution to longevity | Florence Comite, M.D.
May 10, 2026
Florence Comite, M.D., a Yale-trained endocrinologist focused on precision medicine and longevity. She discusses how aging begins in your 30s and the early decline of testosterone. She covers metabolic markers like glucose and A1c, personalized hormone strategies and genetic testing, plus the limits and promise of AI in medicine.
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Aging Starts In Your Thirties
- Aging begins under the surface in your 30s and is driven by gradual metabolic and hormonal shifts.
- Florence Comite highlights a 1–3% decline in testosterone starting in the 30s that impacts metabolism, muscle, mood, cognition, and cardiovascular risk.
Measure Free Testosterone Not Total
- Measure free testosterone rather than total testosterone to assess biologically active hormone.
- Free testosterone matters because total can be bound by sex hormone binding globulin, so labs reporting population averages can miss individual deficiency.
Five Biomarkers Drive Age-Related Risk
- Five core biomarkers become abnormal with age and are actionable for longevity.
- Florence Comite lists fasting glucose, fasting insulin, hemoglobin A1c, cholesterol ratio, and CGM patterns as primary targets to prevent chronic disease.
