Health Report Mapping the environmental exposures that impact human health
Jul 11, 2025
Marko Popovich, an ophthalmologist and retinal surgeon from the University of Toronto, discusses the intriguing concept of the human exposome, which maps environmental factors impacting health. He highlights concerns about GLP-1 drugs linked to wet age-related macular degeneration, emphasizing the need for safer prescribing guidelines. The conversation also addresses health disparities faced by Indigenous Australians regarding kidney disease and transplantation, exploring the systemic barriers that hinder equitable healthcare access.
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GLP-1s Linked to Eye Risk
- GLP-1 drugs for diabetes and weight loss may double the risk of wet age-related macular degeneration in elderly diabetics.
- Despite relative risk increase, the absolute risk remains low, affecting few individuals.
Eye Checks Before GLP-1 Drugs
- Patients should discuss with their doctor any history of retinal or optic nerve conditions before starting GLP-1 drugs.
- It's advisable to consult an ophthalmologist for monitoring if on GLP-1 therapy, especially with existing eye conditions.
Inequity in Kidney Transplant Listing
- Indigenous Australians face significant delays and barriers to getting on kidney transplant waitlists compared to non-Indigenous Australians.
- These delays include incomplete assessments and lack of eligibility evaluations, contributing to inequity.