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Personal Sleep-Deprivation Story
- Louisa Nicola describes sleeping only 5.5 hours a night while training and working up to ~100 hours weekly, which destroyed her sleep quality.
- She cut sleep to keep training and work, then began a decade-long quest to optimize sleep with many interventions.
Glycine Lowers Core Temperature
- Glycine's primary sleep effect appears to come from lowering core body temperature and promoting heat loss through distal vasodilation.
- This thermoregulatory action facilitates entry into deep sleep and reduces sleep fragmentation for hot sleepers.
Mechanism: Glycine Crosses BBB
- Animal data show glycine crosses the blood–brain barrier and facilitates vasodilation, supporting body heat loss mechanisms.
- That physiological pathway aligns with observed improvements in sleep quality in human studies.