Everyday Wellness: Midlife Hormones, Menopause, and Science for Women 35+

Ep. 513 Fasting Doesn’t Work the Same After 35 – The Shocking Truth About Hormones, Hunger & Aging with Dr. Stephanie Estima | Metabolic Health & Menopause

Oct 29, 2025
Dr. Stephanie Estima, a physician specializing in women's health and longevity, joins the discussion to tackle navigating perimenopause while parenting. She offers insights on adjusting fasting practices in midlife and explores the complex relationship between dairy and inflammation. The conversation dives into the role of hormesis in building resilience through stressors like exercise, and the importance of strength training combined with cardio for optimal health. Listeners will gain practical tips for balancing hormones and enhancing overall well-being.
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INSIGHT

Fasting Is Contextual

  • Fasting is a tool, not inherently good or bad; usability depends on goals like hypertrophy.
  • To build muscle you often must eat more frequently to provide substrate for protein synthesis.
ADVICE

Don't Let OMAD Cause Frailty

  • Avoid chronic OMAD or extreme caloric restriction if your goal is long-term strength and bone health.
  • Do prioritize regular protein intake and progressive strength training to prevent frailty.
INSIGHT

Hunger Cues Become Unreliable

  • Chronic caloric restriction blunts hunger and thirst cues, making appetite unreliable.
  • You may need to eat beyond diminished hunger signals to restore healthy intake and body composition.
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