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Partial Agonist Mechanism
- Partial agonists can decrease excessive dopamine action or increase low dopamine action.
- They act like a "dimming light switch" compared to antagonist "on/off switches".
Remembering the "Two Pips and a Rip"
- Dr. Wang uses "ABC" to remember aripiprazole, brexpiprazole, and cariprazine.
- Aripiprazole is the second most dispensed antipsychotic in the US, after quetiapine.
Aripiprazole Metabolism
- Be cautious of aripiprazole's metabolism via CYP2D6 and CYP3A4.
- Consider enzyme inhibitors or inducers.