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The novel is set in Warwickshire in the late 16th century and revolves around the life of Agnes, the wife of William Shakespeare, and their children. It fictionalizes the events surrounding the death of their son Hamnet, who died of the plague in 1596 at the age of eleven. The story delves into the grief and emotional turmoil faced by the family, especially Agnes, and how this tragedy influenced Shakespeare's writing, including his play 'Hamlet'. The narrative alternates between different timelines, exploring Agnes's early life, her marriage, and the years following Hamnet's death. The book is a poignant study of motherhood, childhood, and the depths of grief, offering a vivid portrayal of family life during the Tudor period.