Could NAD IVs Be Bad For You (& How To Boost NAD Naturally), With Dr. Nichola Conlon

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Apr 25, 2026

Dr. Nichola Conlon, molecular biologist and founder of Nuchido who researches NAD biology, discusses what NAD does in cells and why it declines with age. She critiques NAD IVs and patches and explains how inflammation and NAMPT drive NAD loss. She outlines why flooding with precursors can strain methylation and describes a systems-based approach (TIME+) that targets NAMPT, CD38, and methylation support.

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INSIGHT

NAMPT Is The Bottleneck For NAD Recycling

Cells mainly maintain NAD via an internal salvage pathway that recycles nicotinamide back into NAD using the NAMPT enzyme.
Conlon highlights NAMPT as the critical enzyme that responds to NAD demand by recycling precursors into NAD.

INSIGHT

NAD Halves Roughly Every 20 Years

NAD levels decline roughly by half every 20 years from birth, driving reduced repair and energy with age.
This decline is driven more by falling NAMPT activity than by lack of dietary precursors, says Conlon.

ADVICE

Don't Flood With Precursors Without Fixing NAMPT

Avoid relying only on flooding the body with NR or NMN precursors when NAMPT activity is down.
Conlon compares it to loading raw material into a factory whose machines (NAMPT) are broken, so output stalls.

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Full Show Notes: https://bengreenfieldlife.com/nadplus

In this fascinating episode, Dr. Nichola Conlon, molecular biologist and founder of Nuchido, breaks down what NAD actually is, what it does inside your cells, and why most popular strategies for boosting it, including NAD IVs, patches, and high-dose NR or NMN, may be fundamentally flawed based on molecular biology.

You’ll discover why NAD declines by half every 20 years, why the NAMPT enzyme and not a shortage of raw material is the real bottleneck, and why flooding the body with precursors without fixing the salvage pathway can actually strain your methylation pathways rather than raise NAD.

You’ll also explore how inflammation through the cluster of differentiation 38 (CD38) enzyme silently drains NAD faster than almost anything else, what a gold standard double-blind placebo-controlled crossover clinical trial on Nuchido TIME+ actually showed, and why NAD sits at the intersection of energy production, cellular repair, sleep, skin health, and biological aging.

Dr. Nichola Conlon (BSc, MRes, PhD) specializes in cellular aging. After a career in drug development, Dr. Nichola founded Nuchido, driven by her belief that cutting-edge science should not lie hidden. At Nuchido, Dr. Nichola’s work focuses on delivering disruptive innovation in the field of anti-aging, rejuvenation, and healthspan. It has led to the development of Nuchido TIME+, a dietary supplement clinically proven to boost NAD+ and reverse biological age. Unlike standard precursors such as NMN or NR, Nuchido TIME+ uses a systems-based approach to target the root causes of NAD+ decline.

👉You can use code BEN20 to save 20% off your first purchase of Nuchido TIME+ here.

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