High Performance Health

Muscle, Menopause & GLP-1s: How to Protect Your Strength While Losing Fat | Dr Jack Mosley

Jul 25, 2025
Guest
Jack Mosley
Dr. Jack Mosley, a GP registrar and author of "Food Noise," dives into the complexities of food cravings and the powerful role of GLP-1 medications like Ozempic. He discusses how 'food noise' is shaped by genetics and emotions, leading to cravings that can derail nutrition efforts. The conversation highlights the importance of combining GLP-1s with healthy lifestyle changes, including regular exercise and resistance training, especially during menopause. He also addresses the risks of rapid weight loss on muscle preservation and overall health.
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ADVICE

Protect Muscle During Weight Loss

  • To protect muscle while losing weight on GLP-1 drugs, incorporate resistance training and ensure sufficient protein intake.
  • Basic bodyweight exercises done at home can maintain muscle and offset up to 40% lean mass loss seen during weight loss.
ADVICE

Use Bioimpedance to Track Muscle

  • Using a bioimpedance scale at home can help track muscle mass changes consistently to preserve lean tissue during weight changes.
  • Consistent measurement conditions are essential for accurate monitoring over time.
INSIGHT

Weight Loss Reveals Skin Aging

  • Rapid weight loss can reveal underlying skin aging due to stretched elastin fibers, creating effects like "Ozempic face."
  • Weight loss actually reduces biological aging by improving metabolic health despite changes in appearance.
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