The Changelog: Software Development, Open Source Biocomputing on human neurons (Interview)
71 snips
Aug 14, 2025 Dr. Ewelina Kurtys, a pioneering neuroscientist and co-founder of FinalSpark, leads an intriguing exploration into biocomputing using human neurons. She shares insights on lab-grown brain organoids and their potential to tackle AI’s energy consumption challenges. Kyle Galbraith, CEO of Depot, highlights the intersection of software efficiency with groundbreaking biocomputing techniques. The discussion dives into transforming digital signals to neurotransmitter interactions and the future implications of merging biological intelligence with AI, sparking excitement for potential advancements in technology.
AI Snips
Chapters
Transcript
Episode notes
Growing Mini-Brain Organoids
- FinalSpark grows neurosphere organoids ~0.5 mm with ~10,000 neurons over ~3 months and connects them to a remote platform.
- These organoids currently support experiments but cannot yet process images, audio, or video.
Unstable Biology Is A Core Challenge
- Major roadblocks include unknown neural encoding and the inherent plasticity of living tissue, causing variable responses.
- FinalSpark built an automated lab to run many repeatable experiments and discover reproducible control patterns.
Programming With Electricity And Neurochemistry
- FinalSpark programs neurons via electrical stimulation and timed chemical feedback like dopamine and serotonin.
- They use neurotransmitter release as reward signals to shape neural behavior in reinforcement-like loops.