Tiny Matters

'A cage of ovulating females': The development and testing of the oral birth control pill

Jan 22, 2025
Suzanne Janad, a retired FDA historian who studied women's health history, and Annette Ramirez de Arellano, a public health professor focused on Puerto Rican health policy, discuss the development and testing of the oral birth control pill. They cover early scientific experiments, controversial trials in Puerto Rico, ethical failures and consent issues, dosing problems and side effects, and how policy and racism shaped the pill's history.
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INSIGHT

Margaret Sanger's Complicated Legacy

  • Margaret Sanger was pivotal for birth control advocacy but also worked with eugenicists and spoke to the KKK, creating a complex legacy.
  • The podcast stresses acknowledging both her contributions and her racist associations like endorsing Buck v. Bell.
INSIGHT

Progesterone Stopped Ovulation And Sparked Human Trials

  • The pill's development hinged on hormone biology, specifically using progesterone to stop ovulation.
  • Gregory Pincus showed oral progesterone suppressed rabbit ovulation, prompting human trials led by John Rock and funded by Catherine McCormick.
INSIGHT

No Informed Consent Allowed Testing On Institutionalized Women

  • In the 1950s there was no legal requirement for informed consent, so patients at a mental hospital were given the pill without consent.
  • Informed consent rules only arrived after the 1962 Kefauver-Harris Amendments following thalidomide revelations.
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