On Purpose with Jay Shetty

WORLD’S TOP OBGYN Dr. Aliabadi: The #1 Hormone Problem Affecting Millions of Women (And The 4 Changes That Can Reverse It)

51 snips
Mar 11, 2026
Dr. Thaïs Aliabadi, OBGYN and fertility expert focused on PCOS and endometriosis, challenges medical gaslighting and poor diagnosis. She covers undiagnosed PCOS, insulin resistance as the first domino, chronic inflammation, mental health links, how to spot abnormal period pain, endometriosis diagnosis and treatment, and practical screening and fertility preparation steps.
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INSIGHT

Hormones Rewire The Brain In PCOS

  • Hormone imbalances in PCOS (unstable estrogen, low progesterone, high androgens) directly alter brain chemistry, lowering serotonin and dopamine and heightening amygdala activity.
  • This creates anxiety, depression, brain fog, low motivation, and craving-driven eating disorders linked to PCOS physiology.
ADVICE

Painful Periods Are A Red Flag

  • Treat severe period pain as abnormal and suspect endometriosis when pain disrupts life, causes vomiting, painful sex, chronic bloating, bladder or bowel symptoms.
  • Seek evaluation rather than accepting pain as 'normal'; early recognition prevents long-term harm.
INSIGHT

Endometriosis Is A Neuroimmune Pain Amplifier

  • Endometriosis implants bleed and inflame outside the uterus, grow nerve fibers, and can sensitize the central nervous system causing chronic pain amplification.
  • The condition is neuroimmune and can spread pain to bladder, bowel, legs, and diaphragm depending on implant location.
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