The Peter Attia Drive #31 - Navdeep Chandel, Ph.D.: metabolism, mitochondria, and metformin in health and disease
02:22:24
Mitochondrial DNA Vulnerability
- Mitochondrial DNA's nuclear location makes it vulnerable.
- High antioxidant levels in the mitochondrial matrix offer some protection.
Mitochondrial Decline in Aging
- Mitochondrial function declines with age, but its impact is unclear.
- Navdeep Chandel believes this decline might not be rate-limiting.
Metformin's Mechanism
- Metformin, a diabetes drug, acts as a mild mitochondrial complex I inhibitor.
- This inhibition may trigger beneficial stress responses.
Get the Snipd Podcast app to discover more snips from this episode
Get the app 1 chevron_right 2 chevron_right 3 chevron_right 4 chevron_right 5 chevron_right 6 chevron_right 7 chevron_right 8 chevron_right 9 chevron_right 10 chevron_right 11 chevron_right 12 chevron_right 13 chevron_right 14 chevron_right 15 chevron_right 16 chevron_right 17 chevron_right 18 chevron_right 19 chevron_right 20 chevron_right 21 chevron_right 22 chevron_right 23 chevron_right 24 chevron_right 25 chevron_right 26 chevron_right 27 chevron_right 28 chevron_right 29 chevron_right 30 chevron_right 31 chevron_right 32 chevron_right 33 chevron_right 34 chevron_right 35 chevron_right 36 chevron_right 37 chevron_right 38 chevron_right 39 chevron_right 40 chevron_right 41 chevron_right 42 chevron_right 43 chevron_right 44 chevron_right 45 chevron_right 46 chevron_right 47 chevron_right 48 chevron_right 49 chevron_right 50 chevron_right 51 chevron_right 52 chevron_right 53 chevron_right 54 chevron_right 55 chevron_right 56 chevron_right 57 chevron_right 58 chevron_right
Introduction
00:00 • 5min
The Biggest Thing in Organ Transplantation?
05:07 • 3min
What's the T C A?
07:59 • 2min
The End of an Enzime
10:21 • 2min
What Is the Major Function of Mitochondria?
12:19 • 2min
Is This Part of a Programmed Cell Death?
14:15 • 5min
Antioxidants in Cancer and Sepsis
19:29 • 2min
Mitocondria as Signalling Organels
21:45 • 2min
The Punch Line Is Still the Same
23:23 • 3min
Is There Apoptosis?
26:15 • 2min
Anti-Apoptotic Proteins in Cancer
27:47 • 2min
Complex One Is the Coolest Mitocondrio Complex
30:10 • 2min
I'm Going to Hold on to Them, Right?
32:05 • 2min
I'm Not Smart Enough, but I Can't Think of It.
34:33 • 2min
Is Mitochondrial D and a Toxic?
36:45 • 2min
Is It Possible to Release Mitochondrial Dna?
39:14 • 2min
Can a Mitochondrial Dione Modify Gene Expression?
41:43 • 3min
Is There a Bias in Mitochondrial Function?
44:25 • 3min
Is Age Limiting?
46:56 • 2min
Is Mito C a Good Anti-Occurrence?
48:28 • 2min
Met Foreman
50:07 • 3min
Metforeman Is Affecting Your Microbiome
53:32 • 2min
The Anti-Inflammatory Properties of Matforman
55:06 • 2min
Glucos to Parvate - What's That Signal?
56:49 • 2min
Navigating Metabolism
58:47 • 2min
Met Foreman and Its Antidibetic Perties
01:01:06 • 3min
Metforeman for Cancer, Is It a Complex One Inhibition?
01:03:58 • 2min
Met Foreman - Is Complex One Refractory?
01:06:02 • 2min
Anti-Cancer Effects - Is Complex One a Cause of Cancer?
01:07:58 • 2min
Do You Think the Anti-Cancer Effects Are Due to Metforeman?
01:09:37 • 3min
Metforeman Is a Good Anti-Cancer Agent
01:12:12 • 2min
The Importance of Mitocondria Inhibition in Cancer Therapy
01:14:07 • 2min
Cancer and the Mitochondrials
01:16:02 • 2min
The Cancer Cell Is Not Optimizing for Energetics
01:17:50 • 2min
Cancer
01:19:57 • 2min
Is There a Causal Role in Complex Diseases?
01:22:15 • 2min
Is Mita Condria Nesivretumer Genesis?
01:24:38 • 4min
Psychlometablis
01:28:55 • 3min
Do Sematic Mutations of the Nuclear Genum Cause Alzheimer's Disease?
01:31:53 • 2min
Is My Metform an Anti-Inflammatory?
01:33:45 • 2min
Gene Therapy for Prostate Cancer
01:35:37 • 2min
Is There a Benefit in Eating an Orange?
01:37:47 • 3min
Is There a Risk of Taking Anti-Occurrence?
01:40:20 • 3min
Is There a Mechanism by Which Met Foreman Reduces Inflammation?
01:43:36 • 2min
The Anti Aging Effects of Met Foreman
01:45:30 • 2min
Metforeman, Is It Getting Into Immune Cells?
01:47:44 • 2min
Is There a Connection Between Anti-Inflammatories and Inflammatory Cells?
01:49:21 • 3min
Is Mito Cue an Anti-Occurrence Supplement?
01:52:06 • 2min
Is My Metforeman Picking Up Quarters in Front of a Tricycle?
01:53:54 • 5min
Is Complex One Loss Associated With Parkinson's?
01:58:51 • 2min
Cortis Al Interaction With Mitochondria
02:00:44 • 2min
Do You Know What's Your Insolent Levels?
02:02:45 • 3min
Hyperthyroidism, Is It a Problem?
02:05:24 • 2min
Do You Have a Glass of Wine?
02:07:30 • 3min
Are You Going to Leave Em Hanging?
02:10:29 • 3min
Is the Pratamed Study Randomized?
02:13:14 • 3min
Do Ketogenic Diets Make Mice Insolent Resistant?
02:16:39 • 3min
How to Get the Right Answer to Dietary Problems
02:19:50 • 3min
In this episode, Nav Chandel, a professor of medicine and cell and molecular biology at Northwestern University, discusses the role of mitochondria and metabolism in health and disease. Nav also provides insights into the mitochondria as signaling organelles, antioxidants, and metformin's multifaceted effects on human health, among many topics related to well-being.
We discuss:
- What got Nav interested in mitochondria [5:00];
- Reactive oxygen species (ROS) [16:00];
- Antioxidants: helpful or harmful? [20:00];
- Mitochondria as signaling organelles [22:00];
- Hydrogen peroxide (H2O2) [25:00];
- Mitochondrial DNA [28:00];
- Mitochondria and aging [45:00];
- Metformin [52:45];
- Metformin and the gut microbiome [54:00];
- Metformin as complex I inhibitor and the importance of the NADH/NAD ratio [1:01:00];
- Anticancer benefits of metformin [1:07:45];
- Mitochondrial function is necessary for tumorigenesis [1:15:00];
- Are somatic mutations the result of mitochondrial dysfunction? [1:31:30];
- Vitamins and antioxidants [1:37:00];
- Targeting inflammation in disease [1:43:00];
- NAD precursors [1:45:45];
- MitoQ [1:52:00];
- Metabolite toxicity [1:56:30];
- Cortisol and healthy aging [2:02:00];
- Nav turns the tables and asks Peter how he deals with the "So what should I eat?" question during social encounters [2:09:00]; and
- More.
Learn more at www.PeterAttiaMD.com