New Discoveries about the Life Cycle of Toxoplasma Gondii—Laura Knoll, PhD—Department of Medical Microbiology & Immunology at the University of Wisconsin-Madison

Professor Laura Knoll is a parasitologist who joins the podcast today to discuss some of her research on a type of parasite called toxoplasma gondii.

She explains the following:

• Where toxoplasma gondii is found and why the sexual stage of its life cycle is only found in cats
• How humans can become infected with toxoplasma gondii, and why most people will never know they are affected and may never need toxoplasma gondii treatment
• How toxoplasma gondii has evolved mechanisms to manipulate the host, such as a rodent that loses its fear of predator urine and actually becomes attracted to it

Toxoplasma gondii is a parasite that can infect every warm-blooded animal on the planet, including humans. This parasite has the fascinating ability to enter muscle tissue and neurons in the brain to enact behavioral changes in the host. For example, a rodent infected with toxoplasma gondii will be attracted to the scent of predator urine rather than fearful of it, thereby exposing themselves to predation and allowing the parasite to continue thriving in other hosts—such as the cat.

Interestingly, the cat intestine is the only place where the sexual life cycle stage of toxoplasma gondii is found, which means the cat can shed infectious oocysts which can potentially put humans at risk of contracting toxoplasma gondii. However, Dr. Knoll explains that the vast majority of people who are chronically infected with this parasite have no idea, and suffer no negative consequences.

She explains how it can become a problem in people who have compromised immune systems, and the mechanism of host-parasite interaction that can occur in non-human animals and pregnant women who have never before been exposed to the parasite.

Until this past year, there was no way to research the sexual life cycle of toxoplasma gondii without using cats as research subjects, but thanks to Dr. Knoll and her team, the specific reason that the sexual stage only occurs in cats has been identified, which has enabled them to induce the sexual stage in mice.

With a mouse model, the opportunities for research have increased significantly and paved the way for the potential development of vaccines that could be administered to cats and livestock that carry and can pass on infectious oocytes.

For more, visit https://mmi.wisc.edu/staff/knoll-laura/.