The Primal Shift 132: I Tested a Fasting Supplement for a Year — Here's What It Did to My Biological Age | Chris Rhodes, CEO of Mimio Health
Your body already knows how to live to 120 in perfect health. It's just not doing it. That realization is what sent Dr. Chris Rhodes down the fasting research path during his PhD in nutritional biochemistry at UC Davis.
His argument? Most people doing 16:8 intermittent fasting aren't getting nearly the benefits they think they are. The body doesn't flip into fasting mode until glycogen stores are depleted, which typically takes 20 to 24 hours. Autophagy, stem cell regeneration, and the real anti-inflammatory benefits don't peak until around 72 hours.
In this episode, Dr. Rhodes, creator of Mimio – the world's first fasting mimetic supplement – explains what his team discovered when they tracked metabolites during 36-hour fasts in healthy subjects, as well as how they isolated four synergistic molecules that recreate fasting benefits at the cellular level.
We also dig into something personal. Almost a year ago, I started supplementing with Mimio and tracked my biological age using TrueAge epigenetic testing before, during, and after.
The result? My pace of aging slowed to 0.85 – meaning that for every calendar year, I'm only aging about 10 months biologically.
Rhodes walks me through what the epigenetic markers actually mean, why some of my results seem contradictory on the surface, and why the phenotype matters more than the genotype when it comes to practical health decisions.
We also get into why fasting can disrupt hormonal cycles through caloric restriction signaling, why elite athletes rarely have exceptional longevity despite peak fitness, and why combining actual fasting with Mimio may produce better results than either one alone.
Try Mimio and get 20% off your first purchase with code MICHAELKUMMER: https://mimiohealth.sjv.io/qWzkOg
About Chris Rhodes: Dr. Chris Rhodes, PhD, spent 8 years researching fasting at UC Davis before discovering that specific molecules produced during a fast can reduce inflammation, fight oxidative stress, and support metabolic health. That research led him to create Mimio, the world's first fasting mimetic supplement, backed by three clinical studies and designed to deliver measurable longevity benefits without changing your diet or lifestyle.
Dr. Chris Rhodes on TikTok: https://www.tiktok.com/@thatnutritiondr Website: https://mimiohealth.com/
Learn more:
73: NAD Supplements That Actually Work: https://www.primalshiftpodcast.com/73-nad-supplements-that-actually-work/
62: Biological Age Test Review: Epigenetics Explained Simply | Hannah Went: https://www.primalshiftpodcast.com/62-biological-age-test-review-epigenetics-explained-simply-hannah-went/
63: HbA1c Levels Explained: Why They May Be High Without High Blood Sugar: https://www.primalshiftpodcast.com/63-hba1c-levels-explained-why-they-may-be-high-without-high-blood-sugar/
Thank you to this episode's sponsor, Apollo Neuro!
Apollo is a wearable that uses gentle sound wave vibrations to signal safety to your nervous system, helping you feel calmer, more focused, and less reactive throughout the day.
Check out my full Apollo review: https://michaelkummer.com/health/apollo-neuro-review/
Get $60 off with my discount code PRIMALSHIFT: https://michaelkummer.com/go/apolloneuro
In this episode: 00:00 Fasting mimetic breakthrough
02:25 Experiment setup TrueAge
04:13 Why fasting extends life
06:14 How long to fast
09:11 Fasting risks and hormones
13:59 Longevity versus performance
18:02 Mimio [How it works]
20:39 Clinical results and trials
24:17 TrueAge report walkthrough
32:57 Immune markers vs feeling healthy
36:45 Can you change epigenetics
39:45 Pace of aging results
45:04 Hormetic stress and inflammation
50:11 Food and postprandial inflammation
57:05 Wrap up
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[Medical Disclaimer]
The information shared on this video is for educational purposes only, is not a substitute for the advice of medical doctors or registered dietitians (which I am not) and should not be used to prevent, diagnose, or treat any condition. Consult with a physician before starting a fitness regimen, adding supplements to your diet, or making other changes that may affect your medications, treatment plan, or overall health.
[Affiliate Disclaimer]
I earn affiliate commissions from some of the brands and products I review on this channel. While that doesn't change my editorial integrity, it helps make this channel happen. If you'd like to support me, please use my affiliate links or discount code.
#Mimio #Longevity