The Diary Of A CEO with Steven Bartlett Most Replayed Moment: Mouthwash REVERSES The Benefits Of Exercise! Dr Nathan Bryan
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Apr 3, 2026 
Dr Nathan Bryan, a nitric oxide researcher and biochemist, dives into why mouthwash and fluoride may disrupt the oral microbiome. He explores how that links to blood pressure, circulation, and exercise. He also gets into sugar’s impact, why many beet products miss the mark, antacids and nutrient absorption, plus nasal breathing and sunlight.
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Ditch Fluoride Toothpaste For Oral Microbiome Health
- Avoid fluoride toothpaste and switch to a non-fluorinated option, according to Nathan Bryan.
- He argues fluoride is absorbed through the mouth, calls it all risk and no benefit, and notes U.S. toothpaste labels say to call poison control if swallowed.
Tongue Scraping Helps Unless You Use Mouthwash
- Use a tongue scraper, but do not follow it with antiseptic mouthwash.
- Nathan Bryan says scraping increases tongue microbiome diversity, while scraping plus mouthwash is the worst combination because it lets antiseptic penetrate deeper into tongue crypts.
Mouthwash May Reverse Exercise Benefits
- Nathan Bryan says mouthwash can cancel the cardiovascular benefits of exercise by disrupting nitric oxide production.
- His mechanism is that killing oral bacteria reduces nitric oxide, constricts blood vessels, and raises blood pressure.
