The Dr. Leaf Show What if Your Brain Isn’t Broken—It’s Just NAD Depleted? A Deep Dive into NAD Supplements with Guest Dr. Andrew Salzman of Wonderfeel
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Sep 10, 2025 
Join Andrew Salzman, a Harvard-trained physician and NAD expert, as he sheds light on the surprising science of brain health. He reveals that cognitive decline is not a given! Discover the critical role of NAD+ in brain function and how its levels decline with age, impacting everything from memory to mental clarity. Andrew shares practical tips to boost brain energy, counteract aging, and enhance longevity. This conversation is a must-listen for anyone looking to keep their mind sharp well into their golden years!
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We Burn Away NAD Faster With Age
- Two causes of NAD decline are reduced synthesis and accelerated consumption with aging.
- The dominant driver is increased consumption by enzymes that rise with age.
CD38: The NAD Drain
- CD38 is a major enzyme that increases with age and cleaves NAD, acting like a metabolic drain.
- High CD38 can explain tissue-specific declines such as ovarian failure and accelerated aging.
CD38 Rise Linked To Menopause
- Salzman describes how rising CD38 near ovarian eggs chews NAD and halts ovulation, causing menopause.
- In animal models, keeping CD38 low preserved ovulation into extreme ages.
