Count to 10 - Anaesthetic Primary Podcast EP45 – Glomerular Filtration, Tubular Function & Renal Acid-Base | Anaesthetic Primary Topic | Renal Physiology | CT10
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Nov 18, 2025 Explore the fascinating endocrine roles of the kidneys, including renin production and its impact on blood pressure regulation. Dive into glomerular filtration with insights on its defining characteristics and mechanisms. Understand how tubular function is crucial for sodium, potassium, and glucose handling. Delve into the intricacies of renal acid-base balance, including bicarbonate reabsorption and ammonia excretion. Finally, revisit important learning points through a review of past questions.
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Tmax, Renal Threshold And Splay Explained
- Understand Tmax and renal threshold: Tmax is transporter capacity, threshold is plasma concentration where saturation appears, and the difference is 'splay'.
- For glucose, Tmax ≈15 mmol/L and threshold ≈12 mmol/L, explaining early glycosuria onset.
Know Segmental Sodium And Water Reabsorption
- Learn segmental reabsorption percentages: PCT ~65% for Na+ and water, TAL ~25% Na+, DCT/collecting ~10% and collecting variable for water (ADH).
- Remember aldosterone acts on late DCT/collecting duct and small % changes in Na+ reabsorption markedly alter volume.
Potassium Secretion Depends On Flow And Aldosterone
- Potassium handling is flow‑ and aldosterone‑dependent; principal cells secrete K+, flow washes luminal K+ gradient, and intercalated cells exchange K+ for H+.
- Aldosterone increases basolateral Na/K ATPase boosting K+ secretion in the lumen.