JACC This Week AI, Polygenic Risk Scores, and Antithrombotic Therapy | JACC This Week
Sep 15, 2025
This discussion dives into the transformative role of artificial intelligence in cardiovascular medicine, advocating for responsible practices. Listeners learn about a compelling registry study on treating right-sided endocarditis and the value of polygenic risk scores in assessing heart failure. Highlights include the multifaceted causes of myocardial infarction in younger adults, particularly among women. The conversation also tackles the impacts of blood pressure management during surgery and examines long-term strategies for antithrombotic therapy after PCI, emphasizing precision in clinical approaches.
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Aspiration Shows Promise In Right-Sided Endocarditis
- Percutaneous mechanical aspiration achieved ~90% procedural success in a high-risk right-sided endocarditis cohort.
- Complications occurred in ~13% and a composite of death, embolism, or urgent surgery was 18%, reflecting high baseline risk.
Registry Reflects Changing Endocarditis Epidemiology
- The CLEAR IE Registry described 256 patients (median age 43) at 19 U.S. centers with many people who inject drugs and device-related infections.
- Editorialists argue PMA may shift from salvage to part of the future standard of care.
Genetics Reveal Hidden Heart Failure Risk
- A validated polygenic risk score predicted new-onset heart failure beyond clinical risk factors and NT-proBNP in ~75,000 people.
- The study suggests genetics can reveal hidden risk and enable earlier, precision prevention strategies.