Egg Health: The Science of NAD+ Sirtuins - with Dr. Mark Ratner

I am so excited to share this conversation with you. In this episode, I sit down with Dr. Mark Ratner, Chief Science Officer at Theralogix, to talk about a topic I've become incredibly passionate about: NAD+ and its role in egg quality and fertility. If you've been wondering what NAD+ actually is, why your eggs need it, and whether supplementation could make a real difference in your IVF or egg freezing outcomes, this is a must-listen.

We get into the science of how NAD+ and sirtuins work together in our cells, why their decline with age is such a big deal for egg health, and the emerging research — from mouse studies to a promising new human trial — suggesting that boosting NAD+ levels could improve fertilization and pregnancy rates. I also share a personal story about a patient whose results completely blew me away after she started NAD+ supplementation on her own. This is the kind of conversation that gets me fired up about the future of fertility medicine.

In this episode, we cover:

• What NAD+ is and how it's present in every cell of your body
• The role of mitochondria in egg development and why eggs require more energy than any other cell
• What sirtuins are and how SIRT1 appears to regulate ovarian reserve
• How the age-related decline in NAD+ and sirtuins creates a "double whammy" for egg quality
• The connection between NAD+, chromosomal abnormalities (aneuploidy), and diminished ovarian reserve
• Key findings from mouse studies and a new human study showing doubled fertilization and clinical pregnancy rates with NAD+ boosting
• How to start supplementing and what to look for

My Book, The Egg Whisperer Way comes out in Summer of 2026. Click here to order yours on Amazon.

Resources:

• Theralogix website: theralogix.com — Use discount code EGG for ~15% off
• The IVF Class at The Egg Whisperer School
• The Egg Whisperer Show podcast on Spotify and Apple Podcasts

  Dr. Aimee's Supplement Stack information

  Subscribe to my YouTube channel for more fertility tips! Join Egg Whisperer School Subscribe to the newsletter to get updates Dr. Aimee Eyvazzadeh is one of America's most well known fertility doctors. Her success rate at baby-making is what gives future parents hope when all hope is lost. She pioneered the TUSHY Method and BALLS Method to decrease your time to pregnancy. Learn more about the TUSHY Method and find a wealth of fertility resources at www.draimee.org.