The Genius Life 570: GLP-1s, Food Addiction, and the Psychology of Craving | Luke Cook
Apr 26, 2026
Luke Cook, entrepreneur and wellness creator behind Shakewell, shares quick takes on GLP-1 drugs, nicotine as a nootropic, and how ultra-processed foods hijack reward systems. They riff on relationship effects from rapid weight change, simple “boy kibble” meal strategies to curb cravings, and the ethics and future of AI in health and creative work.
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GLP‑1s Reduce General Craving Not Just Appetite
- GLP‑1 drugs blunt general wanting by targeting brain reward circuits beyond appetite.
- Luke Cook and Max discuss evidence these drugs reduce cravings for food, alcohol, gambling and may dampen romantic desire and bonding signals.
Weight Loss And Drugs Can Change Who You Find Attractive
- Weight loss and hormonal/psychological changes on GLP‑1s can shift dating preferences and relationship dynamics.
- Max and Luke note interactions with birth control and self‑confidence may change partner selection and attraction.
Gym Owner Noticed Rapid GLP‑1 Face Transformations
- Luke sees people rapidly transform on GLP‑1s in his gym, noticing dramatic facial and jawline changes within weeks.
- He likens fast visible shifts to someone who disappears quickly compared with typical months‑long fat loss.
